ME 406 COURSE PROFILE
DEGREE PROGRAM: Mechanical Engineering

COURSE NUMBER: ME 406 COURSE TITLE: Biomechanics for Eng Students
REQUIRED COURSE OR ELECTIVE COURSE: Elective TERMS OFFERED: Fall or Winter
TEXTBOOK / REQUIRED MATERIAL: PRE / CO-REQUISITES: MECHENG 320 and MECHENG 382. II (3 credits)
COGNIZANT FACULTY: E. Meyhofer
COURSE TOPICS:
  1. Introduction to biological principles: cells, self-replication, complex systems and evolution
  2. Biomolecules: energetics, catabolism and biosynthesis, protein structure-function relationship of protein machines, catalysis; nucleic acids and information
  3. Cytoskeleton: microtubules and actin filaments
  4. Biomolecular motors: force generation, step size analysis, single molecule mechanics
  5. Mechanics of the cytoskeleton: force generation and active polymerization
  6. Cell motility: mechanical models and molecular mechanisms
  7. Mechanics of DNA and RNA
  8. Skeletal muscle: structure, physiology, muscle mechanics, energetics and control, models
  9. Cardiac and insect flight muscle, diversity and adaptations
  10. Hearing: Mechanics and molecular mechanisms
  11. Vision: optics, signal processing from the retina to the visual cortex
  12. Respiration and gas exchange
  13. Mechanics of circulation and blood rheology
  14. Viscoelastic materials
  15. Stiff and fibrous composites
  16. Biological ceramics: from bones to egg shells
  17. Biomimetics
  18. Animal locomotion: swimming, flying, running and crawling, cost of locomotion, neuromuscular control
  19. Scaling problems: from bones to metabolic rates and ecosystems
BULLETIN DESCRIPTION: Fundamental properties of biological systems, followed by a quantitative, mechanical analysis. Topics include mechanics of the cytoskeleton, biological motor molecules, cell motility, muscle, tissue and bio-fluid mechanics, blood rheology, bio-viscoelasticity, biological ceramics, animal mechanics and locomotion, biomimetics, and effects of scaling. Individual topics will be covered on a case by case study basis.
COURSE STRUCTURE/SCHEDULE: Lecture: 2 days per week at 1.5 hours

COURSE OBJECTIVES:
for each course objective, links to the Program Outcomes are identified in brackets.

  1. To teach the fundamental principles that characterize life and biosystems [1]
  2. To teach key aspects of molecular mechanisms of cellular function [1]
  3. To teach how biosystems transduce energy and information [1]
  4. To teach biomechanical principles that govern how organs and the human body work [1]
  5. To teach principle and unique properties of biological materials [1.2.5-11]
  6. To study animal locomotion [1]
  7. To introduce students to cutting-edge bioengineering research methods [9,10,11]
  8. To apply quantitative (undergraduate) engineering knowledge to selected biological systems [1,5]
  9. To introduce engineering students to research opportunities in the life sciences [9]
  10. To relate fundamental bioengineering approaches to health-related biomedical research [8, 9, 10]
  11. To teach how biology impacts engineering and bio-nanotechnology [9, 10]
COURSE OUTCOMES:
for each course outcome, links to the Course Objectives are identified in brackets.
  1. Understand the basic principles that characterize living system
  2. Understand how molecular mechanisms control cellular function
  3. Understand energy transduction in biosystems
  4. Understand the quantitative, mechanistic aspects of organ and human body function
  5. Understand how biological systems store and retrieve information
  6. Understand the bioengineering foundations of animal locomotion
  7. Understand the central role of ecosystems and energetics
  8. Understand modern, quantitative, experimental research methods in bioengineering
  9. Improve technical writing and communication skills
  10. Understand the societal impact of bioengineering
ASSESSMENT TOOLS:
for each assessment tool, links to the course outcomes are identified
  1. Homework problems
  2. Review and critique of selected primary literature
  3. Written term papers

PREPARED BY: E. Meyhofer
LAST UPDATED: 06/08/2011